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. 2023 Mar 31;18(11):2526–2534. doi: 10.4103/1673-5374.371372

Figure 4.

Figure 4

caRheb improves visual dysfunction following ONC.

(A) Schematic diagram of the position of silver electrodes in mouse FVEP. (B–D) caRheb attenuated the impairment of visual function by ONC. Representative FVEP tracings of sham, EGFP, and caRheb groups 21 days post-crush (dpc). (E, F) Quantitative amplitude and latency of the P1 wave 21 days post-crush (mean ± SD, n = 8–9 per group). **P < 0.01, ****P < 0.0001, one-way analysis of variance with Bonferroni’s post hoc test. AAV: Adeno-associated virus; caRheb: constitutively active Ras homolog enriched in brain; EGFP: enhanced green fluorescent protein; FVEP: flash visual evoked potential; Sham: sham operation; ONC: optic nerve crush.