Figure 4.

Pathological findings in patients with CV2/CRMP5 antibody-associated paraneoplastic neurological syndrome.

(A) Hematoxylin and eosin-stained section from the caudate nucleus showing perivascular and parenchymal infiltrates of mature lymphocytes, diffuse neuronal loss, and reactive (hypertrophic) gliosis. (B) Glial fibrillary acidic protein-immunostained section showing reactive gliosis. (C) CD8-immunostained section showing strong reactivity, consistent with cytotoxic/suppressor T lymphocytes. (D) CD4 (T-helper cell)-immunostained section showing only rare positivity. Original magnification 500×. Reproduced with permission from Muehlschlegel et al. (2005). CRMP5: Collapsin response mediator protein 5.