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. 2023 Mar 15;18(11):2429–2435. doi: 10.4103/1673-5374.371367

Figure 3.

Figure 3

Effect of LZ-3 on brain histopathology in rats on day 26 after cerebral ischemia.

(A) Representative images of hematoxylin-eosin staining of the cortex show that LZ-3 reduced damage to the cortex on day 26 after reperfusion. LZ-3 (2 or 4 mg/kg) or edaravone treatment reduced the cortical damage caused by cerebral ischemia. Arrows indicate nerve cells in the cortex. Scale bars: 2 mm (low-magnification images) and 200 μm (enlarged images). (B, C) LZ-3 reduced the number of TUNEL+ cells in the rat cortex post-stroke. LZ-3 (2 or 4 mg/kg) or edaravone treatment reduced the number of apoptotic cells in the cortex after stroke. Arrows indicate apoptotic nerve cells in the cortex. Scale bar: 100 μm. (D, E) LZ-3 reduced hippocampal structure disruption post-stroke. LZ-3 and edaravone treatment increased the number of nerve cells in the hippocampal CA1 region compared with saline. Arrows indicate nerve cells in the hippocampal CA1 region. Scale bar: 100 μm. Data are expressed as mean ± SD (n = 3). ##P < 0.01, ###P < 0.001, vs. sham group; *P < 0.05, **P < 0.01, vs. model group (one-way analysis of variance followed by Tukey’s post hoc test). Mod: Model group; TUNEL: TdT-mediated dUTP nick-end labeling.