Additional Table 3.
The comparison of Clinical Diagnostic Criteria for CRPS adopted by the IASP in 2012 and the characteristics observed in our CPIP model mice
| Budapest clinical diagnostic criteria for CRPS adopted by the IASP in 2012 | Characteristics observed in our CPIP mice |
|---|---|
| 1. Continuing pain, which is disproportionate to any inciting event | CPIP model mice showed persistent pain. |
| 2. Must report at least one symptom in three of the four following categories: | Not applicable (The symptoms can not be measured in CPIP mice) |
| Sensory: Reports of hyperalgesia and/or allodynia | Not applicable |
| Vasomotor: Reports of temperature asymmetry and/or skin color changes and/or skin color asymmetry | Not applicable |
| Sudomotor/Edema: Reports of edema and/or sweating changes and/or sweating asymmetry | Not applicable |
| Motor/Trophic: Reports of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin) | Not applicable |
| 3. Must display at least one sign* at time of evaluation in two or more of the following categories: | The signs of CPIP mice were consistent with most criteria |
| Sensory: Evidence of hyperalgesia (to pinprick) and/or allodynia (to light touch and/or deep somatic pressure and/or joint movement) | The CPIP mice showed hyperalgesia to von Frey filament stimulation and radiant heat stimulation, accompanied by spontaneous pain (Figure 1D-K) |
| Vasomotor: Evidence of temperature asymmetry and/or skin color changes and/or asymmetry | After ischemia/reperfusion, the temperature of ipsilateral hind paw of our CPIP mice was obvious increased in a short time (Figure 1C) |
| Sudomotor/Edema: Evidence of edema and/or sweating changes and/or sweating asymmetry | After ischemia/reperfusion, the thickness of ipsilateral hind paw of our CPIP mice was obviously increased in a short time (Figure 1A and B) |
| Motor/Trophic: Evidence of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin) | The distance traveled and velocity of CPIP mice in the open field test were decreased at the late stage of CPIP generation (Figure 1L and M) |
| 4. There is no other diagnosis that better explains the signs and symptoms | Not applicable |
CPIP: Chronic postischemia pain; CRPS: complex regional pain syndrome; IASP: International Association for the Study of Pain.