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. 2023 Mar 15;18(11):2520–2525. doi: 10.4103/1673-5374.371371

Figure 4.

Figure 4

Correlation analyses between the mean cortical thickness and clinical parameters, including disease durations, EDSS, and cognitive scale scores.

(A) Heatmap of the correlational r-values between the mean cortical thickness in the brain regions showing significant differences from controls, and clinical parameters including disease durations, the EDSS scores, and cognitive scale scores (i.e., DSST, TMT-A, TMT-B). (B, C) In the left rMFG, mean cortical thickness positively correlated with DSST scores and negatively correlated with TMT-A and EDSS scores. (D, E) In the right rMFG, mean cortical thickness positively correlated with the DSST scores and negatively correlated with TMT-A, TMT-B, and EDSS scores. Pearson’s (ROI-based surface values vs. TMT-B scores) and Spearman’s (ROI-based surface values vs. disease durations, EDSS, DSST, and TMT-A scores) correlation analyses were applied. *P < 0.05, **P < 0.01. DSST: Digit Symbol Substitution Test; EDSS: Expanded Disability Status Scale; L: left; R: right; rMFG: rostral middle frontal gyrus; SFG: superior frontal gyrus; TMT-A: Trail Making Test (subscale A); TMT-B: Trail Making Test (subscale B).