Table 3.
Overview of bilateral areas of cluster-level significant effects of cortical thickness reduction in patients with NMOSD with normal-appearing brain tissue compared to healthy controls
| Overlay of atlas region | Hemisphere | Cluster size | Peak MNI coordinates (mm) | FDR-corrected P-value | ||
|---|---|---|---|---|---|---|
|
| ||||||
| x | y | z | ||||
| 79% rostralmiddlefrontal | L | 243 | –21 | 63 | 2 | 0.014 |
| 19% superiorfrontal | ||||||
| 2% lateralorbitofrontal | ||||||
| 98% superiorfrontal | L | 180 | –9 | 53 | 39 | 0.045 |
| 2% rostralmiddlefrontal | ||||||
| 86% rostralmiddlefrontal | R | 553 | 26 | 58 | 7 | < 0.001 |
| 10% superiorfrontal | ||||||
| 4% frontalpole | ||||||
Atlas labeling was conducted according to the Desikan-Killiany atlas. FDR: False discovery rate; L: left; MNI: Montreal Neurological Institute; NMOSD: neuromyelitis optica spectrum disorder; R: right.