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. 2023 Mar 15;18(11):2370–2376. doi: 10.4103/1673-5374.371346

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Copyright: © Neural Regeneration Research

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Post-translational modifications of TFEB.

The key sites of TFEB modifications are shown in the left panels, including phosphorylation, acetylation, ubiquitination, oxidation, and other modifications (SUMOylation, PARsylation, and glycosylation). The related effectors of TFEB modifications are shown in the right panels, including kinases, phosphatases, HDACs, KATs, and E3 ligases. Ac: Acetylation; AD: N-terminal transcriptional activation domain; bHLH: basic helix-loop-helix region; C: cysteine; E: glutamic acid; G: glycine; Gl: glycosylation; Gln rich: glutamine-rich domain; K: lysine; KATs: lysine acetyltransferases; NLS: nuclear localization signal; Ox: oxidation; P: phosphorylation; Pa: PARsylation; Pro rich: proline-rich domain; S: serine; Su: SUMOylation; T: threonine; TFEB: transcription factor EB; Ub: ubiquitination; V: valine; Zip: leucine zipper. Created with Adobe Illustrator CC 2018.