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. 2023 Mar 15;18(11):2370–2376. doi: 10.4103/1673-5374.371346

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Copyright: © Neural Regeneration Research

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A schematic illustration showing how a combination of LYECs with ATTEC, AUTAC, LYTAC, AUTOTAC, GlueTAC, or AbTAC can be used as a potential therapeutic approach to ameliorate neurodegenerative diseases.

AbTAC: Antibody-based PROTAC; ATTEC: AuTophagosome-TEthering Compound; AUTAC: Autophagy-TArgeting Chimera; AUTOTAC: AUTOphagy-TArgeting Chimera; CPP: cell-penetrating peptide; GlueTAC: nanobody-based PROTAC; LSS: lysosome-sorting sequence; LYECs: LYsosome-Enhancing Compounds; LYTAC: LYsosome-TArgeting Chimera; M6P: mannose 6-phosphate; POI: protein of interest. Created with Adobe Illustrator CC 2018.