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. 2023 Mar 15;18(11):2545–2552. doi: 10.4103/1673-5374.371374

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Copyright: © Neural Regeneration Research

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Conjoint analysis of m6A methylation and mRNA expression after SNI.

(A) Histogram displaying the differentially expressed genes at the indicated time points after SNI. (B, C) Venn diagram and heatmap (|fold-change| ≥ 2.0 and P < 0.05) of differentially expressed genes at three different time points after SNI. Nlrp1 (red) was selected for subsequent validation. (D–F) Four-quadrant graph showing the association between mRNA m6A methylation and transcriptome level at 3, 7 and 14 days after SNi. diff. log2.fc: mRNA m6A methylation regulation; log2(fc): gene regulation. Down: downregulation; Hyper: hypermethylation; Hypo: hypomethylation; UP: upregulation. Dots indicate |fold-change|≥ 2.0, of which with P < 0.05 highlighted by red (Hyper-UP), yellow (Hypo-UP), blue (Hyper-Down) and green (Hypo-Down). Adgrd1: Adhesion G protein-coupled receptor D1; Atf3: activating transcription factor 3; CT010467: 18s RNA, related sequence 5; Gal: galanin and GMAP prepropeptide; Gm10222: predicted gene 10222; Gm15564: predicted gene 15564; Gm23935: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; Gm24270: predicted gene 15564; Gm5898: predicted gene 5898; Gpr151: G protein-coupled receptor 151; Ifi44: interferon-induced protein 44; Ifit1: interferon induced protein with tetratricopeptide repeats 1; Lars: leucyl-TRNA synthetase 1; Mettl7a3: methyltransferase like 7A3; Ppp1r3g: protein phosphatase 1, regulatory subunit 3G; Rn7sk: RNA component of 7SK nuclear ribonucleoprotein; Rps13-ps: ribosomal protein S13; SNI: spared nerve injury; Sprr1a: small proline-rich protein 1A; Tgtp1: interferon gamma induced GTPase; Tubb6: tubulin, beta 6 class V.