TABLE 6.

Serum renal function test of hyperlipidemic volunteers at baseline, day 30, and day 60 during Phase 2 (mean ± SD).

	Control	250 mg OPP
Urea (mmol/L)
Day 1	4.03 ± 0.99	4.27 ± 1.15
Day 30	4.30 ± 0.80	4.46 ± 1.11
Day 60	4.01 ± 0.95	4.34 ± 1.10
Creatinine (mmol/L)
Day 1	69.44 ± 16.74	69.88 ± 16.35
Day 30	73.40 ± 16.67b	73.68 ± 17.32a
Day 60	71.76 ± 16.63a	73.04 ± 15.38a
Calcium (mmol/L)
Day 1	2.24 ± 0.08	2.23 ± 0.08
Day 30	2.26 ± 0.07	2.31 ± 0.11a
Day 60	2.28 ± 0.06	2.31 ± 0.08a
Phosphate (mmol/L)
Day 1	1.14 ± 0.12	1.14 ± 0.18
Day 30	1.14 ± 0.14	1.18 ± 0.18
Day 60	1.15 ± 0.14	1.17 ± 0.16
Uric acid (mmol/L)
Day 1	0.35 ± 0.08	0.36 ± 0.10
Day 30	0.36 ± 0.09	0.36 ± 0.10
Day 60	0.33 ± 0.09c	0.35 ± 0.10
Sodium (mmol/L)
Day 1	137.92 ± 1.12	138.84 ± 1.37
Day 30	137.28 ± 1.31	137.76 ± 1.45a
Day 60	137.56 ± 1.76	137.52 ± 1.53
Potassium (mmol/L)
Day 1	4.38 ± 0.43	4.33 ± 0.39
Day 30	4.36 ± 0.34	4.32 ± 0.38
Day 60	4.60 ± 0.42c	4.50 ± 0.40c
Chloride (mmol/L)
Day 1	105.24 ± 1.54	105.88 ± 1.86
Day 30	103.92 ± 2.08a	103.48 ± 2.00b
Day 60	104.00 ± 1.35	103.76 ± 1.54

^aSignificantly different compared to day 1 within the group (p < 0.05).

^bSignificantly different compared to day 1 within the group (p < 0.001).

^cSignificantly different compared to day 30 within the group (p < 0.05).