Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Basic overview of possible pathological events leading to DN. Chronic hyperglycemia leading to cellular damage increases DAMPs and PAMPs. This encourages inflammatory cells such as monocytes, macrophages, T cells and neutrophils to begin a positive feedback loop of immune cell recruitment and inflammation. This leads to kidney fibrosis and a decline in kidney function, leading to DN.
