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Basic overview of possible events leading to DPN. Chronic hyperglycemia alternatively activated glucose metabolism pathways result in increases of cytotoxic byproducts and end products. An increase in AGE - RAGE interaction results in an increase of proinflammatory cytokines leading to a positive feedback loop of immune cell activation. This leads to the destruction of nerve cell myelin, leading to a reduction in nerve functionality resulting in diabetic neuropathy.
