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. 2023 Jul 7;17:1226630. doi: 10.3389/fncel.2023.1226630

FIGURE 7.

FIGURE 7

Permissive and non-permissive RXR dimers. In addition to forming homodimers, RXR acts as a universal heterodimerization partner with other nuclear hormone receptors. (A) Permissive heterodimers act in a cooperative or synergistic fashion while non-permissive heterodimers generally require ligand binding to the non-RXR monomer to induce transcriptional activity. (B) RXRs are ubiquitously expressed and regulate the proliferation, differentiation, function, and survival of numerous cell subtypes in the brain. Box 1, This enables the preferential RXR agonist IRX4204 to reduce inflammation and stimulate the production of new vascular, glial, and neuronal cells necessary for NVU repair. Box 2, The TR agonist T3 enhances the therapeutic benefits of IRX4204 by synergistically inducing the differentiation of oligodendrocyte progenitor cells into myelin producing oligodendrocytes. (See section “6.5. Activation of nuclear hormone receptors to mobilize diverse cell subtypes necessary for NVU repair” for abbreviations and mechanistic details).