TABLE 1.

Clinical and treatment features

Case	Age at symptoms onset, y	Clinical features at disease onset	Clinical features at treatment onset	Duration of symptoms before treatment onset	Duration since treatment initiation	Treatment benefit	Treatment discontinuation
1	26	Foot dystonia	Dysphagia, dysarthria, oro‐facial dystonia, chorea of upper limb, mild cerebellar signs	33 y	62 m	Benefit: +, slight improvement of the last sign that appeared: apathy	Duration of 8 m with rapid degradation
2	46	Cerebellar syndrome	Cerebellar and extra‐pyramidal syndrome	11 y	141 m	Benefit: ++, mild improvement (UPDRS scores from 26 to 19)	30 m with worsening of gait, balance, extrapyramidal syndrome, depression, apparition of dystonia
3	28	Spastic paraparesis	Spastic paraparesis	3 y	122 m	Benefit: +++, from 1 km to unlimited walking range	41 m with worsening of spastic paraplegia
4	48	Extra‐pyramidal and cerebellar syndrome	Extra‐pyramidal and cerebellar syndrome	4 y	41 m	Benefit: ++++, improvement of cerebellar signs (SARA from 10 to 4)	No discontinuation

y = years; m = month.