Table 2.
Multilevel model predicting epigenetic age acceleration using Horvath’s pan-tissue clock
| Predictor | b [95% Confidence interval] |
|---|---|
| Age | 0.30* [0.06, 0.54] |
| Birthweight (≥2500 g) | 0.02 [−0.22, 0.26] |
| Sex (male) | −0.03 [−0.21, 0.16] |
| Gestational age | 0.02 [−0.06, 0.10] |
| Maternal age | 0.00 [−0.03, 0.03] |
| Maternal BMI | 0.00 [−0.04, 0.04] |
| Parity (multigravida) | −0.20 [−0.52, 0.13] |
| Delivery mode (vaginal) | −0.02 [−0.24, 0.19] |
| Alcohol (none) | 0.19 [−0.10, 0.49] |
| Naïve CD8+ T | 0.003** [0.001, 0.006] |
| CD8+CD28-CD45RA- | 0.02 [−0.02, 0.05] |
| Plasma blast | 1.32** [0.44, 2.20] |
| CD4+ T | −0.79 [−3.23, 1.66] |
| Natural killer | 1.67 [−1.74, 5.09] |
| Monocytes | −1.95 [−4.50, 0.61] |
| Granulocytes | −1.39* [−2.48, −0.30] |
| War trauma | −0.09 [−0.19, 0.02] |
| Chronic stress | 0.02 [−0.02, 0.05] |
| Age × birthweight (dichotomized around 2500 g) | −0.39** [−0.64, −0.13] |
| N (observations) | 141 |
| N (individuals) | 61 |
| R 2 (fixed)1 | 0.24 |
| R 2 (marginal)2 | 0.62 |
**p < 0.01; *p < 0.05.
1Fixed R2 quantifies variance explained by fixed effects alone.
2Marginal R2 quantifies variance explained by fixed and random effects combined.