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. 2023 Jul 7;10:1225251. doi: 10.3389/fcvm.2023.1225251

Table 2.

Antihypertensive medication classes and agents selected across HDP type.

Medication class agent All (N = 1,276) Eclampsia/severe preeclampsia (N = 260) Chronic with superimposed preeclampsia (N = 354) Preeclampsia (N = 425) Gestational hypertension (N = 237) P value
Beta blockers 1,011 (79.2%) 222 (85.4%) 299 (84.5%) 329 (77.4%) 161 (67.9%) <0.001
Labetalol 956 (74.9%) 213 (81.9%) 289 (81.6%) 309 (72.7%) 145 (61.2%) <0.001
Metoprolol 46 (3.6%) 8 (3.1%) 14 (4.0%) 15 (3.5%) 9 (3.8%) 0.946
Propranolol 26 (2.0%) 6 (2.3%) 6 (1.7%) 6 (1.4%) 8 (3.4%) 0.388
Calcium channel blockers 406 (31.8%) 57 (21.9%) 158 (44.6%) 126 (29.7%) 65 (27.4%) <0.001
Nifedipine 378 (29.6%) 54 (20.8%) 142 (40.1%) 123 (28.9%) 59 (24.9%) <0.001
Amlodipine 23 (1.8%) 3 (1.2%) 12 (3.4%) 3 (0.71%) 5 (2.1%) 0.035
Diltiazem 11 (0.86%) 2 (0.77%) 8 (2.3%) 0 (0.0%) 1 (0.42%) 0.003
Diuretics 86 (6.7%) 15 (5.8%) 33 (9.3%) 25 (5.9%) 13 (5.5%) 0.176
Furosemide 45 (3.5%) 12 (4.6%) 13 (3.7%) 13 (3.1%) 7 (3.0%) 0.711
HCTZ 32 (2.5%) 3 (1.2%) 17 (4.8%) 6 (1.4%) 6 (2.5%) 0.012
Vasodilators 275 (21.6%) 88 (33.9%) 83 (23.5%) 85 (20.0%) 19 (8.0%) <0.001
Hydralazine 261 (20.5%) 84 (32.3%) 80 (22.6%) 83 (19.5%) 14 (5.9%) <0.001
Nitroglycerin 17 (1.3%) 5 (1.9%) 3 (0.85%) 3 (0.71%) 6 (2.5%) 0.178
Alpha-Agonist 70 (5.5%) 10 (3.9%) 31 (8.8%) 9 (2.1%) 20 (8.4%) <0.001
Methyldopa 56 (4.4%) 7 (2.7%) 28 (7.9%) 5 (1.2%) 16 (6.8%) <0.001
Clonidine 16 (1.3%) 3 (1.2%) 5 (1.4%) 4 (0.94%) 4 (1.7%) 0.854
Number of antihypertensive medication classes used <0.001
One 839 (65.8%) 156 (60.0%) 185 (52.3%) 298 (70.1%) 200 (84.4%)
Two 322 (25.2%) 81 (31.2%) 102 (28.8%) 105 (24.7%) 34 (14.3%)
Three or more 115 (9.0%) 23 (8.8%) 67 (18.9%) 22 (5.2%) 3 (1.3%)