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. 2023 Jul 7;14:1196033. doi: 10.3389/fimmu.2023.1196033

Figure 3.

Figure 3

Schematic illustration showing that signals from injured parenchymal cells stimulate the release of cytokines and chemokines from resident macrophages and the induction of monocyte adhesion molecules on the endothelium to stimulate vascular sprouting. DAMPS: Danger-associated molecular patterns; TNF-α: tumor necrosis factor alpha; MCP-1: Monocyte chemoattractant protein-1. Scheme modified and adapted from “Melgar-Lesmes, P.; et al. Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. J Hepatol. 2015 Oct;63 (4):917-25. doi: 10.1016/j.jhep.2015.05.011”.