Table 1.
Chemokines and chemokine receptors involving monocytes and endothelial cells.
| Receptor | Chemokine ligands | Receptor expressed on | Ligands mostly expressed/secreted by | Reference |
|---|---|---|---|---|
| CCR1 | CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), CCL14 (HCC1) | Monocytes, T cells, dendritic cells | Monocytes macrophages, endothelial cells, T cells, dendritic cells, neutrophils, epithelial cells, fibroblasts | (40, 41) |
| CCR2 | CCL2 (MCP-1), CCL8 (MCP-2), CCL7 (MCP-3), CCL13 (MCP-4), CCL16 (HCC4) | Monocytes, endothelial cells, dendritic cells | Monocytes, macrophages, endothelial cells, T cells, epithelial cells, fibroblasts | (40, 41) |
| CCR5 | CCL3 (MIP-1α), CCL4 (MIP-1β), CCL5 (RANTES), CCL11 (eotaxin), CCL14 (HCC1), CCL16 (HCC4) | Monocytes, macrophages, endothelial cells, T cells, dendritic cells | Monocytes, macrophages, endothelial cells, T cells, epithelial cells, leukocytes | (40, 41) |
| CCR8 | CCL1 (I309) | Monocytes, T cells, dendritic cells | Monocytes, T cells, mast cells | (40, 41) |
| CXCR1 | CXCL8 (IL-8), CXCL6 (GCP2) | Monocytes, neutrophils | Macrophages, endothelial cells, T cells, epithelial cells, fibroblasts | (40, 41) |
| CXCR2 | CXCL8 (IL-8), CXCL1 (GROα), CXCL2 (GROβ), CXCL3 (GROγ), CXCL5 (ENA-78), CXCL6 (GcP2) | Monocytes, microvascular endothelial cells, neutrophils | Monocytes, macrophages, endothelial cells, T cells, epithelial cells, fibroblasts, mast cells | (40, 41) |
| CXCR3-B | CXCL4 (PF4), CXCL9 (MIG), CXCL10 (IP-10), CXCL11 (I-TAC) | Microvascular endothelial cells, T cells, natural killer cells | Monocytes, endothelial cells, T cells, neutrophils, epithelial cells, fibroblasts, cancer cells | (40, 41) |
| CX3CR1 | CX3CL1 (fractalkine) | Monocytes, macrophages, T cells, dendritic cells, smooth-muscle cells, natural killer cells | Endothelial cells, T cells | (40, 41) |