Table 2.
Monocyte adhesion molecules involved in transendothelial migration.
| Adhesion molecule | Ligands | Ligand expressed on | Function | Reference |
|---|---|---|---|---|
| L-selectin (CD62L) | Fucosylated sialoglycoproteins | Endothelial cell | Rolling | (48, 49) |
| PSGL-1 | P-selectin (CD62P) E-selectin (CD62E) |
Endothelial cell | Rolling | (50, 51) |
| PSGL-1 | L-selectin | Monocyte | Monocyte recruitment | (52, 53) |
|
LFA1
(αLβ2-integrin or CD11a–CD18) |
ICAM1/CD54 | Endothelial cell | Arrest | (24, 54, 55) |
|
VLA4
(α4β1-integrin or CD49d–CD29 |
VCAM1/CD106 | Endothelial cell | Arrest | (24, 54, 55) |
|
Mac1
(αMβ2-integrin or CD11b–CD18 |
ICAM1/CD54 among others |
Endothelial cell | Arrest | (56) |
|
LFA1
(αLβ2-integrin or CD11a–CD18) |
JAM-A | Endothelial cell | Transmigration | (57) |
|
VLA4
(α4β1-integrin or CD49d–CD29 |
JAM-B | Endothelial cell | Transmigration | (58) |
|
Mac1
(αMβ2-integrin or CD11b–CD18 |
JAM-C | Endothelial cell | Transmigration | (59) |
| αXβ2-integrin (CD11c–CD18) | JAM-C | Endothelial cell | Transmigration | (59) |
|
PECAM1
(CD31) |
PECAM1 | Endothelial cell | Transmigration | (60) |
| CD99 | CD99 | Endothelial cell | Transmigration | (61) |