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. 2023 Jul 7;14:1166756. doi: 10.3389/fendo.2023.1166756

Figure 1.

Figure 1

The expression location and form of function of m6A methylases, demethylases and readers. The m6A modification of RNA is dependent on the catalytic effect of methylases and demethylases. The former mainly includes methyltransferase complex with METTL3 as the core, METTL16, METTL4 and METTL5. The latter comprises the FTO and AKLKBH5. The m6A site on RNA can be recognized and combined by different “readers” to influence the RNA following effects by facilitating translation, splicing and affecting stability. METTL3/14/16/5/4, Methyltransferase-like 3/14/16/5/4; WTAP, Wilms tumor 1- associated protein; VIRMA, Vir-like m6A methyltransferase associated; RBM15/15B, RNA binding motif protein 15/15B; ZC3H13, ZCCHC4, zinc finger CCHC domain-containing protein 4; FTO, Fat mass and obesity-associated protein; ALKBH5, AlkB homologue 5; eIF3, Eukaryotic translation initiation factor 3; YTHDC1/2, YTH domain containing 1/2; YTHDF1-3, YTH N6-methyladenosine RNA binding protein 1-3; IGF2BP1-3, Insulin-like growth factor 2 mRNA binding protein 1-3.