T2D	type 2 diabetes
m6A	N6-methyladenosine
IR	insulin resistance
SAM	S-adenosyl methionine
ER	endoplasmic reticulum
TG	triglycerides
IGF1	insulin-like growth factor 1
PDK1	pancreatic and duodenal homeobox 1
ERN1	ER to nucleus signaling 1
XBP-1	X-box protein binding 1
MAFA	MAF bZIP transcription factor A
GSIS	glucose-stimulated insulin secretion
PAX4	paired box 4
GCK	glucokinase
SLC2A2	solute carrier family 2 member 2
SNPs	single nucleotide polymorphisms
FFAs	free fatty acids
JAK	janus kinase
STAT	signal transducer and activator of transcription
C/EBP β	CCAAT enhancer binding protein beta
C/EBPα	CCAAT enhancer binding protein alpha
PPARγ	peroxisome proliferator-activated receptor gamma
FABP4	fatty acid binding protein 4
MCE	mitotic clonal expansion
CCND1	cyclin D1
HFD	high-fat diet
UCP1	uncoupling protein 1
PCG-1α	PPARG coactivator 1 alpha
PRDM16	PR/SET domain 16
RUNX1T1	RUNX1 partner transcriptional co-repressor 1
AMPK	AMP-activated protein kinase
ATG5	autophagy-related 5
ATG7	autophagy-related 7
HIF1-α	hypoxia-inducible factor 1 subunit alpha
GWAS	genome-wide association studies
FASN	fatty acid synthase
SREBP-1c	sterol regulatory element-binding proteins-1c
ACC	acetyl-CoA carboxylase
ACLY	ATP citrate lyase
SCD1	stearoyl-CoA desaturase 1
NLRP3	NOD-like receptor protein 3
DDIT4	damage inducible transcript 4
FOXO1	forkhead box O1
G6PC	glucose-6-phosphatase catalytic subunit
DGAT2	diacylglycerol O-acyltransferase 2
ACVR2a	activin type 2A receptor
PP2A	serine/threonine protein phosphatase 2A
mTOR	mechanistic target of rapamycin kinase
PI3K	phosphoinositide 3-kinase
PDK1	pyruvate dehydrogenase kinase 1
EGFR	epidermal growth factor receptor
INSR	insulin receptor
CDK2	cyclin-dependent kinase 2
GLP-1	glucagon-like peptide-1.