Table 1.

Top 20 AUF-1 target genes ranked according to enrichment factor (AUF-1 IP vs Input) in RIP-Seq experiments.

Gene symbol	Full Name	EF	FDR	Main Functions	References
PRR36	Proline Rich 36	5,73	0,020203	Unknown function	(83)
GLIS2	GLIS Family Zinc Finger 2	4,95	0,00745	Transcription factor	(84, 85)
ZNF385A	Zinc Finger Protein 385A	4,4	5,15E-05	Zinc finger protein	(86)
TCF7L1	Transcription Factor 7 Like 1	4,14	0,003217	Wnt signaling pathway	(87–89)
PIANP	PILR Alpha Associated Neural Protein	3,52	0,000871	Ligand for the paired Ig-like type 2 receptor alpha	(90)
MBD6	Methyl-CpG Binding Domain Protein 6	3,42	2,49E-09	Binds to heterochromatin	(91)
MUC1	Mucin 1, Cell Surface Associated	3,37	1,81E-06	Binds to oligosaccharides by the extracellular domain	(92, 93)
FOXP4	Forkhead Box P4	3,27	7,46E-05	Transcriptor factor	(94, 95)
KDM6B	Lysine Demethylase 6B	3,2	0,000139	Lysine-specific demethylase	(96, 97)
FBRSL1	Fibrosin Like 1	3,09	0,000336	Unknown function	(98)
C1orf226	Chromosome 1 Open Reading Frame 226	2,86	0,039358	Unknown function	(99)
AP001972.5	AP001972.5	2,84	0,032884	Unknown function
STX1B	Syntaxin 1B	2,83	0,012534	Mediator of calcium-dependent synaptic vesicle release	(100)
CRTC1	CREB regulated transcription coactivator 1	2,73	0,001314	Co-activator of the transcription factor CREB	(101)
AL513165.1	AL513165.1	2,66	0,034496	Unknown function
ATXN2L	Ataxin 2 Like	2,6	1,37E-08	Regulator of stress granules	(102)
RNF44	Ring Finger Protein 44	2,6	0,000146	E3 ligase	(103)
IL17RD	Interleukin-17 Receptor D	2,58	0,026678	Orphan receptor member of the IL-17R family	(104, 105)
KIAA1522	KIAA1522	2,58	1,23E-08	Unknown function	(106)
HIVEP3	Human Immunodeficiency Virus Type 1 Enhancer-Binding Protein 3	2,47	0,000702	Transcription factor	(107, 108)

Full list (n=494) in Supplementary Table S4 . EF, Enrichment Factor; FDR, False Discovery Rate.