Table 4.
Ingenuity Pathway Analysis (IPA)-derived selected canonical pathways of AUF-1 targets relevant to COPD.
| Ingenuity Canonical Pathways | p-value | Ratio | Molecules |
| RANK Signaling in Osteoclasts | 8,31764E-05 | 9,62E-02 | TRAF6,MAP3K9,MAPK14,PIK3C2A,PTK2B,MAP3K1,IRS2,PIK3R4,XIAP,PPP3CA |
| Glucocorticoid Receptor Signaling | 0,000234 | 5,43E-02 | PBRM1, PIK3C2A, SMAD3, MAP3K1, ARID2, PIK3R4, TRAF6, TAF1, AR, MAPK14, TGFB1, HSP90AA1, IRS2, NCOR1, NCOR2,SMARCC1, NRIP1, TAF2, PPP3CA |
| PPARα/RXRα Activation | 0,000245 | 6,88E-02 | CAND1,TRAF6,MAPK14,TGFB1,SMAD3,HSP90AA1,NCOA6,BMPR2,NR2C2,NCOR1,BCL3,NCOR2,MED12 |
| Protein Ubiquitination Pathway | 0,002344 | 5,17E-02 | USP14,MED20,USP9X,BIRC6,DNAJC13,ANAPC1,XIAP,TRAF6,USP13,PSMD12,HSP90AA1,USP40,NEDD4L,USP34 |
| p53 Signaling | 0,003090 | 7,08E-02 | MAPK14,PIK3C2A,PLAGL1,CCNK,IRS2,PIK3R4,PML,TP53BP2 |
| EGF Signaling | 0,003981 | 8,57E-02 | MAPK14,PIK3C2A,ITPR2,MAP3K1,IRS2,PIK3R4 |
| TGF-β Signaling | 0,004677 | 7,29E-02 | TRAF6,RUNX3,MAPK14,RNF111,TGFB1,SMAD3,BMPR2 |
| RAN Signaling | 0,005370 | 1,76E-01 | KPNB1,RANBP2,KPNA6 |
| CXCR4 Signaling | 0,006456 | 5,46E-02 | DOCK1,PXN,PAK4,PIK3C2A,ITPR2,GNA12,EGR1,PAK2,IRS2,PIK3R4 |
| Estrogen Receptor Signaling | 0,009772 | 5,84E-02 | MED13,TAF1,MED20,NCOR1,NCOR2,NRIP1,MED12,TAF2 |
| Role of NFAT in Cardiac Hypertrophy | 0,011220 | 4,8E-02 | MAPK14,HDAC2,PIK3C2A,CAMK1D,ITPR2,TGFB1,MAP3K1,IGF1R,IRS2,PIK3R4,PPP3CA |
| SAPK/JNK Signaling | 0,012302 | 6,09E-02 | MAP3K9,PIK3C2A,CRKL,GNA12,MAP3K1,IRS2,PIK3R4 |
| Role of Osteoblasts, Osteoclasts, Chondrocytes in Rheum Arthritis | 0,013803 | 4,66E-02 | TRAF6,MAPK14,PIK3C2A,PTK2B,TGFB1,BMPR2,IRS2,TCF7L1,PIK3R4,XIAP,PPP3CA |
| Osteoarthritis Pathway | 0,016982 | 4,72E-02 | SIK3,FN1,GLIS2,GLI3,TGFB1,SMAD3,CTNNA1,BMPR2,RBPJ,TCF7L1 |
| TNFR1 Signaling | 0,022387 | 0,08 | PAK4,PAK2,MAP3K1,XIAP |
| B Cell Receptor Signaling | 0,027542 | 4,57E-02 | MAP3K9,MAPK14,PIK3C2A,PTK2B,EGR1,MAP3K1,IRS2,PIK3R4,PPP3CA |
| IL-17A Signaling in Airway Cells | 0,029512 | 6,25E-02 | TRAF6,MAPK14,PIK3C2A,IRS2,PIK3R4 |
| CD40 Signaling | 0,030902 | 6,17E-02 | TRAF6,MAPK14,PIK3C2A,IRS2,PIK3R4 |
| CCR3 Signaling in Eosinophils | 0,032359 | 0,05 | PAK4,MAPK14,PIK3C2A,ITPR2,PAK2,IRS2,PIK3R4 |
| DNA Double-Strand Break Repair by Non-Homologous End Joining | 0,035481 | 1,43E-01 | LIG4,LIG3 |
| DNA Methylation, Transcriptional Repression Signaling | 0,036307 | 8,82E-02 | MECP2,HDAC2,DNMT1 |
| ERK/MAPK Signaling | 0,037153 | 4,33E-02 | DOCK1,PXN,PAK4,PIK3C2A,PTK2B,CRKL,PAK2,IRS2 |
| Nitric Oxide Signaling in the Cardiovascular System | 0,038018 | 5,22E-02 | PIK3C2A,ITPR2,HSP90AA1,IRS2,PIK3R4,PDE1C |
| IL-23 Signaling Pathway | 0,040738 | 6,67E-02 | RUNX1,PIK3C2A,IRS2,PIK3R4 |
| Choline Degradation I | 0,042657 | 0,5 | ALDH7A1 |
| Cardiac Hypertrophy Signaling | 0,048977 | 3,94E-02 | MAP3K9,MAPK14,PIK3C2A,TGFB1,GNA12,MAP3K1,IGF1R,IRS2,PIK3R4,PPP3CA |
Full list in Supplementary Table S4 .