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. 2023 Jul 20;21:489. doi: 10.1186/s12967-023-04336-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The immune cell distributions in the ccRCC tissues exhibited scattered and clustered status. A Representative IMC images depicting the clustered and scattered distributions of T cells (CD3), macrophages (CD68) and B cells (CD20). Clustered architecture in P51, P26 and P82 vs scattered architecture in P29, P62 and P77. B Representative IMC images illustrating the ccRCC tissues with scattered (Top panel: P62) and clustered (Bottom panel: P90) immune architectures. C IMC images and corresponding cell distribution maps of ccRCC tissues. Top panel: clustered architecture, P13; Bottom panel: scattered architecture, P81. D Mix score of each ccRCC tissues. The mix scores of P24 and P2 in the cohort were set as the thresholds of clustered and scattered immune architectures, respectively