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. 2023 Jul 20;21:489. doi: 10.1186/s12967-023-04336-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cellular Neighborhood (CN) analysis reflect the cell communities within the ccRCC tissues. A Analysis schedule of CN. The topology of IMC image was represented by categorical dot plot with different colors indicating various CNs. B Heatmap showing the number of CNs across various ccRCC tissues. The numbers were normalized by z-score for visualization. C Categorical dot plots and corresponding IMC images of representative tissues with clustered immune architecture. Top: P25; Bottom: P8. D Categorical dot plots and corresponding IMC images of representative tissues with scattered immune architecture. Top: P62; Bottom: P20