Fig. 5.

TLS-like structure and macrophage/T cell communities in the clustered groups has distinct prognosis. A Heatmap showing CN numbers across ccRCC tissues with clustered immune architecture. Red box denotes the TLS-like structure and blue box denotes the macrophage/T cell communities. Scale bar represents the number of CNs, with a maximum limit of 10. B Representative IMC images and characteristic CNs of the TLS-like phenotypes (P22 and P13). C Representative IMC images and characteristic CNs of the Macrophage/T-clustered phenotypes (P8 and P51). D Comparison of proportions of different cell types in CNs between the TLS-like and Macrophage/T-clustered phenotypes, including B cells, CD8⁺ T cells, GZMB⁺CD8⁺ T cells, CD163⁻ macrophages, CD163⁺ macrophages, Treg cells, T other cells and GZMB⁺CD163⁻ macrophages. E Comparison of survival between the TLS-like and Macrophage/T-clustered phenotypes