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. 2023 Jul 20;21:489. doi: 10.1186/s12967-023-04336-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Scattered group can be divided into immune-cold and -hot phenotypes. A Unsupervised clustering of the ccRCC tissues with scattered immune architecture. Red box reflects the immune-cold phenotype. Scale bar represents the number of CNs, with a maximum limit of 10. B Spatial relationship between the immune (CD3, CD20 and CD68) and non-immune (αSMA, CD31, Vim and Ecad) components in the scattered-CN-cold and scattered-CN-hot phenotypes. C Comparison of the proportion of different cell types between the scattered-CN-cold and scattered-CN-hot phenotypes. D Representative IMC images of the scattered-CN-hot phenotype (P2 and P29). The zoomed areas display the characteristic CNs within the ccRCC tissues