Table 2.
Risk ratios (95% CI) for MACEs according to quartiles of METS‐IR
| METS‐IR index | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| RR (95% CI) | P Value | RR (95% CI) | P Value | RR (95% CI) | P Value | |
| All participants | ||||||
| Q1 (<29.63) | Reference | Reference | Reference | |||
| Q2 (29.63–33.26) | 1.23 (0.88–1.73) | 0.227 | 1.27 (0.90–1.78) | 0.174 | 1.18 (0.95–1.91) | 0.099 |
| Q3 (33.27–37.74) | 1.45 (1.04–2.02) | 0.026 | 1.53 (1.09–2.13) | 0.013 | 1.26 (1.12–2.27) | 0.010 |
| Q4 (>37.74) | 1.93 (1.41–2.64) | 0.000 | 2.08 (1.50–2.88) | 0.000 | 1.47 (1.05–2.77) | 0.000 |
| P for trend | 0.000 | 0.000 | 0.015 | |||
| Per SD increment | 1.44 (1.31–1.58) | 0.000 | 1.50 (1.36–1.66) | 0.000 | 1.38 (1.22–1.57) | 0.000 |
| Without diabetes | ||||||
| Q1 (<29.51) | Reference | Reference | Reference | |||
| Q2 (29.51–33.03) | 1.36 (0.95–1.93) | 0.091 | 1.39 (0.97–1.97) | 0.071 | 1.29 (1.03–2.14) | 0.035 |
| Q3 (33.04–37.28) | 1.53 (1.08–2.16) | 0.016 | 1.59 (1.12–2.25) | 0.009 | 1.34 (1.17–2.47) | 0.005 |
| Q4 (>37.28) | 1.68 (1.20–2.36) | 0.003 | 1.76 (1.25–2.48) | 0.001 | 1.42 (1.18–2.54) | 0.005 |
| P for trend | 0.002 | 0.000 | 0.001 | |||
| Per SD increment | 1.40 (1.26–1.56) | 0.000 | 1.44 (1.28–1.61) | 0.000 | 1.36 (1.19–1.56) | 0.000 |
| Diabetes | ||||||
| Q1 (<31.21) | Reference | Reference | Reference | |||
| Q2 (31.21–36.67) | 1.16 (0.41–3.28) | 0.781 | 1.41 (0.51–4.38) | 0.535 | 1.14 (0.44–4.46) | 0.570 |
| Q3 (36.68–43.46) | 1.31 (0.48–3.62) | 0.599 | 1.78 (0.64–5.29) | 0.299 | 1.23 (0.43–6.22) | 0.475 |
| Q4 (>43.46) | 2.61 (1.05–6.49) | 0.039 | 2.81 (1.38–6.85) | 0.010 | 1.75 (1.11–6.46) | 0.025 |
| P for trend | 0.027 | 0.030 | 0.004 | |||
| Per SD increment | 1.62 (1.22–2.15) | 0.001 | 1.83 (1.35–2.47) | 0.000 | 1.59 (1.11–2.89) | 0.018 |
Model 1 was unadjusted. Model 2 was adjusted for age, sex and WHR. Model 3 was adjusted for all variables in Model 2 plus HbA1c, fasting insulin, LDL, TC, hypertension, hyperlipidemia, current smoking, current drinking, and eGFR at baseline. Values in bold indicate statistical significance (P value < 0.05). CI, confidence interval; MACEs, major adverse cardiovascular events; METS‐IR, metabolic score for insulin resistance; RR, risk ratio; SD, standard deviation.