Training phase of a transcriptomic panel for the identification of LNM in patients with T1 CRC. A) Overview of the study. B) A ROC curve for a 4-miRNA and 5-mRNA panel in serum from training cohort patients (LNP = 5, LNN = 41; AUC: 4-miRNA panel = 0.78, 5-mRNA panel = 0.77, combination panel = 0.86). C) Risk score distribution plot in training cohort patients. Modified risk scores were obtained from individual risk scores by using Youden’s index values from the risk model. D) Forest plots with ORs for each panel risk score status in univariate logistic regression analysis in training cohort patients (ORs: 4-miRNA panel = 8.62, 5-mRNA panel = 8.44, combination panel = 14.22).