Table 3.

Univariate and Multivariate Logistic Regression Analysis for Lymph Node Metastasis

	Univariate analysis			Multivariate analysis
Factors	OR	95% CI	P a	OR	95% CI	P a
Training cohort (N = 46)
Age
(≥67 vs <67)	0.22	0.02–2.10	.19
Sex
(male vs female)	0.58	0.09–3.82	.57
Tumor location
(right vs left)	0.39	0.04–3.82	.42
Tumor size
(≥20 mm vs <20 mm)	1.58	0.24–10.44	.64
Submucosal invasion
(≥1000 μm vs <1000 μm)	<0.01		.99
Budding grade
(≥2 vs 1)	3.57	0.42–30.10	.24
Lymph invasion
(positive vs negative)	1.82	0.27–12.38	.54
Vascular invasion
(positive vs negative)	4.65	0.68–31.91	.12
Transcriptomic panel
(high risk vs low risk)	14.22	1.41–143.68	.025
Validation cohort (N = 142)
Age
(≥67 vs <67)	0.97	0.30–3.16	.96
Sex
(male vs female)	1.33	0.38–4.66	.65
MSI status
(MSI-H vs MSI-L, MSS)	1.22	0.14–10.56	.86
Tumor location
(right vs left)	0.81	0.21–3.15	.76
Tumor size
(≥20 mm vs <20 mm)	7.82	0.98–62.35	.05
Submucosal invasion
(≥1000 μm vs <1000 μm)	<0.01		.99
Budding grade
(≥2 vs 1)	3.89	1.08–13.95	.037	1.70	0.32–9.06	.53
Lymph invasion
(positive vs negative)	3.78	1.08–13.23	.038	1.60	0.29–8.69	.59
Vascular invasion
(positive vs negative)	0.35	0.07–1.68	.19
Transcriptomic panel
(high risk vs low risk)	15.97	3.32–76.82	<.001	8.13	1.43–46.29	.018
Risk-stratification model
(high risk vs low risk)	37.17	4.48–308.35	<.001	17.28	1.82–164.07	.013

MSI, microsatellite instability; MSI-H, high-frequency microsatellite instability; MSI-L, low-frequency microsatellite instability; MSS, microsatellite stable

^aBold P values are statistically significant (P < .05).