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. 2023 Jul 20;38(1):2231170. doi: 10.1080/14756366.2023.2231170

Table 1.

IC50 values of the tested compounds 5a–k and 8a–h against human aldose reductase.

graphic file with name IENZ_A_2231170_ILG0001_B.jpg   graphic file with name IENZ_A_2231170_ILG0002_B.jpg
Comp. R AR inhibition, IC50 (μM)
5a 4-NO2 0.22
5b 4-Cl 0.46
5c 4-Br 0.49
5d 4-F 0.57
5e 4-CH3 0.55
5f 4-OCH3 0.28
5g 3,4,5-triOCH3 0.72
5h 3-NO2 0.51
5k 3-Br 0.41
8a 4-NO2 1.98
8b 4-Cl 0.16
8c 4-Br 0.21
8d 4-F 0.33
8e 4-CH3 0.29
8f 4-OCH3 0.94
8g 3,4,5-triOCH3 0.27
8h 3,4-diOCH3 0.45
Epalrestat – 0.10