. 2023 Jul 20;38(1):2231170. doi: 10.1080/14756366.2023.2231170

Table 2.

Calculated parameters for Lipinski’s rule and Veber’s standards for the hybrids 5a, 5f, 8b, 8c, 8e, and 8g.

Comp.	Mwt^a	nHBA^b	nHBD^c	LogP^d	nVs^e	nRB^f	TPSA^g	% ABS^h
Lipinskiⁱ	≤500	≤10	≤5	≤5	≤1	–	–	–
Veber^j	–	–	–	–	–	≤10	≤140	–
5a	413.36	10	0	3.92	0	6	146.09	58.59
5f	398.39	8	0	3.94	0	6	109.50	71.22
8b	386.88	4	0	5.38	1	3	50.27	91.65
8c	431.33	4	0	5.59	1	3	50.27	91.65
8e	366.46	4	0	5.09	1	3	50.27	91.65
8g	442.51	7	0	4.15	0	6	77.96	82.10
Epalrestat	319.40	4	1	2.76	0	4	89.70	78.05

^{^a}

Molecular weight.

^{^b}

Number of hydrogen bond acceptors.

^{^c}

Number of hydrogen bond donors.

^{^d}

Lipophilicity (O/W).

^{^e}

Number of Lipinski rule violations.

^{^f}

Number of rotatable bonds.

^{^g}

Topological polar surface area.

^{^h}

Percentage of oral absorption.

^ⁱ

Reference values of Lipinski.

^{^j}

Reference values of Veber.