Table 1.
Summary of available data on individuals with diabetes used in SCORE2-Diabetes risk model derivation
| N (%) or mean (SD) | |||
|---|---|---|---|
| SCID | ERFC/UKB | CPRD | |
| Participants | 136 192 | 20 517 | 72 751 |
| Male sex | 72 525 (53%) | 11 485 (56%) | 38 599 (53%) |
| SCORE2 variables | |||
| Age (years) | 65 (11) | 60 (8) | 64 (11) |
| Current smoker | 24 447 (18%) | 2353 (12%) | 11 423 (21%) |
| Systolic blood pressure (mmHg) | 136 (16) | 142 (17) | 136 (16) |
| Total cholesterol (mmol/L) | 4.3 (1.0) | 4.7 (1.1) | 4.4 (1.0) |
| HDL-cholesterol (mmol/L) | 1.3 (0.4) | 1.2 (0.3) | 1.2 (0.4) |
| SCORE2-Diabetes additional variables | |||
| Diabetes age of diagnosis (per 5-years) | 58 (12) | 53 (9) | 58 (11) |
| HbA1c (mmol/mol) | 58 (17) | 55 (20) | 52 (19) |
| eGFR (mL/min/1.73 m2) | 74 (20) | 88 (17) | 76 (17) |
| Follow-up [years, median (5th–95th percentile)] | 10.9 (6.8, 11.0) | 11.3 (2.8, 13.6) | 6.0 (0.8, 11.0) |
| Cardiovascular events | 34 595 | 1864 | 7247 |
| Non-cardiovascular deaths | 21 062 | 1953 | 5211 |
SCID, Scottish Care Information—Diabetes; ERFC, Emerging Risk Factors Collaboration; UKB, UK Biobank; CPRD, Clinical Practice Research Datalink; eGFR, estimated Glomerular Filtration Rate, calculated using the CKD-EPI 2009 equations; HbA1c, glycated haemoglobin, in International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) units.
Table shows summary statistics for datasets before imputation (which was carried out during analysis). A summary of missing data, by data source and variable, is provided in Supplementary data online, Table S2.