Fig. 2.

Cellular uptake of NK-exos^IL−15/21 by HCC cells. (A) Co-culture of Hep3B cells with PKH67-labeled NK-exos, NK-exos^IL−15, NK-exos^IL−21, and NK-exos^IL−15/21 (each 50 μg, green) for 24 h. Internalization was visualized by confocal microscopy. Cell nuclei were stained with Hoechst 33258 (Blue). Scale bars: 20 μm. (B) Uptake levels of NK-exos, NK-exos^IL−15, NK-exos^IL−21, and NK-exos^IL−15/21 by Hep3B cells. All data are presented as the mean ± SD (n = 3). N.S. (no significance) vs. NK-exos. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)