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. 2023 Jul 7;14:1171934. doi: 10.3389/fimmu.2023.1171934

Figure 1.

Figure 1

IL-1R signaling improves survival during S. aureus bacteremia. The S. aureus bacteremia infection was performed on WT, IL-1α–/–, IL-1β–/–, IL-1R–/–, IL-17A/F–/–, and TNF-α–/– mice. (A) Survival (%) of WT, IL-1α–/–, IL-1β–/–, and IL-1R–/– mice (n=7-10 per group, average inoculum = 4.8 × 107 CFUs). (B) Survival (%) of WT, IL-17A/F–/–, and TNF-α–/– mice (n=9-30 per group, average inoculum = 5.4 × 107 CFUs). ‡P < 0.001 and n.s. = not significant; WT versus IL-1α–/–, IL-1β–/–, IL-1R–/–, IL-17A/F–/–, and TNF-α–/– as calculated by log rank (Mantel-Cox) test. Data were combined from at least 2 independent experiments.