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. 2023 Jul 7;14:1171934. doi: 10.3389/fimmu.2023.1171934

Figure 2.

Figure 2

γδ T cell-intrinsic IL-1R signaling promotes survival during S. aureus bacteremia. The S. aureus bacteremia infection was performed on Lck-IL-1R–/–, LysM-IL-1R–/–, S100A8-IL-1R–/–, VE-Cad-IL-1R–/–, CD4-IL-1R–/–, and TCRδ-IL-1R–/– mice. (A) Survival (%) of Lck-IL-1R–/–, LysM-IL-1R–/–, S100A8-IL-1R–/–, VE-Cad-IL-1R–/– mice (n=8-35 per group, average inoculum = 5.4 × 107 CFUs). (B) Survival (%) of WT and CD4-IL-1R–/– mice (n=28-30 per group, average inoculum = 5.4 × 107 CFUs). (C) Survival (%) of WT and TCRδ-IL-1R–/– mice (n=29 per group, average inoculum = 5.4 × 107 CFUs). †P < 0.01, ‡P < 0.001, and n.s. = not significant; WT versus Lck-IL-1R–/–, LysM-IL-1R–/–, S100A8-IL-1R–/–, VE-Cad-IL-1R–/–, CD4-IL-1R–/–, TCRδ-IL-1R–/– as calculated by log rank (Mantel-Cox) test. Data were combined from at least 2 independent experiments.