Table 6.

Adverse events.

	All (n=91)
Symptoms	Any grade	Grade 3-4
Any adverse event	88 (96.7%)	22 (24.2%)
Fatigue	10 (11.0%)	1 (1.1%)
Hypertension	30 (33.0%)	4 (4.4%)
Decreased appetite	23 (25.3%)	3 (3.3%)
Diarrhea	12 (13.1%)	4 (4.4%)
Hypothyroidism	4 (4.4%)	0
Proteinuria	3 (3.3%)	0
Dysphonia	2 (2.2%)	0
Epistaxis	2 (2.2%)	0
Fever	5 (5.5%)	0
Edema	3 (3.3%)	0
Cramps	3 (3.3%)	0
Nausea	13 (14.3%)	0
Vomiting	6 (6.6%)	0
Pneumonia	1 (1.1%)	0
Abdominal distension	2 (2.2%)	0
Hand-foot skin reaction	3 (3.3%)	0
Increased blood bilirubin	22 (24.2%)	4 (4.4%)
Rash	6 (6.6%)	0
Abdominal pain	2 (2.2%)	0
Increased creatinine	1 (1.1%)	0
ALT elevation	24 (26.4%)	0
AST elevation	47 (51.6%)	6 (6.6%)

ALT, alanine transaminase; AST, aspartate aminotransferase.