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. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: N Engl J Med. 2022 Jun 22;387(1):35–44. doi: 10.1056/NEJMoa2201422

Figure 4. Histologic Assessments.

Figure 4.

The first endomyocardial biopsy (Panel A, day 34 after transplantation) showed normal histologic characteristics. The second endomyocardial biopsy (Panel B, day 50) showed interstitial red-cell extravasation, fragmentation, and edema without cellular infiltrate or intravascular thrombosis. The third endomyocardial biopsy (Panel C, day 56) showed some resolution of interstitial edema and red-cell extravasation but also showed evidence of necrotic myocytes. The septum at autopsy (Panels D and E, day 60) showed interstitial edema and red-cell extravasation, myocardial necrosis, scant fibrosis, and central nuclei.