Table 1. Comparison of baseline characteristics between patients with different E2 levels on the trigger day in cleavage group (N = 2217).
| Items | Set 1 E2≤2000 pg/ml |
Set 2 E2 =2001-3000 pg/ml |
Set 3 E2 =3001-4000 pg/ml |
Set 4 E2 >4000 pg/ml |
|---|---|---|---|---|
| N | 1208 | 584 | 320 | 105 |
| Age (years) | 34.5 ± 5.6 | 32.3 ± 5.3a | 32.2 ± 4.6a | 31.6 ± 4.5a |
| BMI (kg/m2), median (Q1-Q3) | 21.64 (20.03-23.73) | 21.23 (19.53-23.06)a | 20.93 (19.53-22.90)a | 20.83 (19.10-22.89)a |
| Duration of infertility (years), median (Q1-Q3) | 3.0 (1.0-5.0) | 2.0 (1.0-4.0) | 3.0 (2.0-5.0) | 3.0 (2.0-5.0) |
| Fertilization method, n (%) | ||||
| IVF | 1011 (83.7%) | 458 (78.4%) | 261 (81.6%) | 81 (77.1%) |
| ICSI | 197 (16.3%) | 126 (21.6%) | 59 (18.4%) | 24 (22.9%) |
| Previous cycle attempts, n (%) | ||||
| 0 | 873 (72.2%) | 481 (82.4%)a | 266 (83.1%)a | 89 (84.8%)a |
| 1-2 | 269 (22.2%) | 95 (16.2%)a | 50 (15.6%)a | 14 (13.3%)a |
| ≥3 | 66 (5.4%) | 8 (1.4%)a | 4 (1.3%)a | 2 (1.90%)a |
| Sterility classification, n (%) | ||||
| primary | 462 (38.3%) | 264 (45.2%)a | 144 (45.0%) | 55 (52.4%)a |
| secondary | 746 (61.7%) | 320 (54.8%)a | 176 (55.0%) | 50 (47.6%)a |
| Ovarian stimulation protocol, n (%) | ||||
| GnRH-antagonist protocol | 830 (68.3%) | 319 (54.6%)a | 151 (47.2%)a | 36 (34.3%)ab |
| GnRH-agonist long protocol | 378 (31.3%) | 265 (45.4)a | 169 (52.8%)a | 69 (65.7%)abc |
| Basal FSH (mIU/ml) | 7.3 ± 2.6 | 6.6 ± 1.9a | 6.5 ± 1.6a | 6.4 ± 2.0a |
| Basal LH (mIU/ml) | 4.7 ± 2.0 | 5.0 ± 2.1a | 5.3 ± 2.0a | 5.0 ± 2.0 |
| Basal E2 (pg/ml) | 37.7 ± 17.1 | 37.0 ± 16.8 | 39.2 ± 15.9 | 36.6 ± 16.1 |
| hCG day FSH (mIU/ml) | 15.7 ± 4.8 | 14.8 ± 4.7a | 14.6 ± 4.7a | 13.4 ± 4.3ab |
| hCG day LH (mIU/ml) | 3.2 ± 2.5 | 3.0 ± 2.3 | 2.7 ± 2.2a | 2.7 ± 1.9 |
| hCG day E2 (pg/ml) | 1309.3 ± 428.5 | 2450.1 ± 282.7a | 3420.9 ± 294.2ab | 4344.46 ± 223.8abc |
| hCG day P (ng/ml) | 0.5 ± 0.3 | 0.7 ± 0.3a | 0.8 ± 0.3ab | 0.8 ± 0.3ab |
| Endometrial thickness (mm), median (Q1-Q3) | 10.7 (9.3–12.1) | 11.0 (9.6–12.6)a | 11.0 (9.6–12.5) | 10.25 (9.03–12.4) |
| No. of retrieved oocytes, median (Q1-Q3) | 6.0 (4.0–8.0) | 10.0 (8.0–13.0)a | 12.0 (10.0–15.0)ab |
14.0 (12.0–17.0)abc |
| No. of inviable embryos, median (Q1-Q3) | 2.0 (2.0–4.0) | 3.0 (2.0–5.0)a | 4.0 (2.0–5.0)a | 4.0 (2.0–5.0)a |
| No. of embryos transferred, n (%) | ||||
| 1 | 222 (18.4%) | 59 (10.1%)a | 32 (10.0%)a | 4 (3.8%)a |
| 2 | 986 (81.6%) | 525 (89.9%)a | 288 (90.0%)a | 101 (96.2%)a |
Notes.
Data are presented as mean ± standard deviation unless otherwise indicated.
a
Compared with set 1, P < 0.05.
b
Compared with set 2, P < 0.05.
c
Compared with set 3, P < 0.05.
Abbreviations
- E2
- estradiol
- Q
- quartile
- BMI
- body mass index
- IVF
- in-vitro fertilization
- ICSI
- intracytoplasmic sperm injection
- FSH
- follicle stimulating hormone
- LH
- luteinizing hormone
- hCG
- human chorionic gonadotropin
- P
- progesterone