Table 2. Comparison of baseline characteristics between patients with different E2 levels on the trigger day in blastocyst group (N = 792).
| Items | Set 1 E2≤2000 pg/ml |
Set 2 E2= 2001–3000 pg/ml |
Set 3 E2= 3001–4000 pg/ml |
Set 4 E2 >4000 pg/ml |
|---|---|---|---|---|
| N | 178 | 310 | 241 | 63 |
| Age (years) | 32.44 ± 4.90 | 31.57 ± 4.45 | 31.63 ± 4.39 | 31.39 ± 4.47a |
| BMI (kg/m2), median (Q1-Q3) | 21.80 (20.15–24.06) | 20.81 (19.53–23.55)a | 20.81 (19.53–23.41)a | 20.31(19.19–22.89)a |
| Duration of infertility (years), median (Q1-Q3) | 3.00 (1.00–5.00) | 3.00 (2.00–4.00) | 2.00 (1.00–4.00) | 2.00 (1.00–5.00) |
| Fertilization method, n (%) | ||||
| IVF | 151 (84.8%) | 244 (78.7%) | 190 (78.8%) | 58 (92.1%) |
| ICSI | 27 (15.2%) | 66 (21.3%) | 51 (21.2%) | 5 (7.9%) |
| Previous cycle attempts, n (%) | ||||
| 0 | 144 (80.9%) | 268 (86.5%) | 201 (83.4%) | 58 (92.1%) |
| 1-2 | 29 (16.3%) | 37 (11.9%) | 38 (15.8%) | 4 (6.4%) |
| ≥3 | 5 (2.8%) | 5 (1.6%) | 2 (0.8%) | 1 (1.5%) |
| Sterility classification, n (%) | ||||
| primary | 72 (40.4%) | 138 (44.5%) | 109 (45.2%) | 19 (30.2%) |
| secondary | 106 (59.6%) | 172 (55.5%) | 132 (54.8%) | 44 (69.8%) |
| Ovarian stimulation protocol, n (%) | ||||
| GnRH-antagonist protocol | 119 (66.9%) | 207 (66.8%) | 144 (59.8%) | 34 (53.9%) |
| GnRH-agonist long protocol | 59 (33.1%) | 103 (33.2%) | 97 (40.2%) | 29 (46.1%)ab |
| Basal FSH (mIU/ml) | 6.56 ± 2.05 | 6.53 ± 2.24 | 6.33 ± 1.75 | 6.01 ± 1.63 |
| Basal LH (mIU/ml) | 4.51 ± 1.85 | 5.13 ± 2.00a | 5.44 ± 2.05a | 5.29 ± 2.08a |
| Basal E2 (pg/ml) | 33.47 ± 16.02 | 37.11 ± 15.11a | 38.75 ± 16.37a | 37.70 ± 14.94a |
| hCG day FSH (mIU/ml) | 13.53 ± 3.85 | 13.37 ± 3.96 | 13.60 ± 4.12 | 13.13 ± 3.83 |
| hCG day LH (mIU/ml) | 2.52 ± 1.86 | 3.00 ± 2.16a | 2.99 ± 2.08a | 3.07 ± 1.93 |
| hCG day E2 (pg/ml) | 1520.91 ± 359.46 | 2494.17 ± 292.65a | 3484.82 ± 270.79ab | 4358.72 ± 268.01abc |
| hCG day P (ng/ml) | 0.55 ± 0.27 | 0.69 ± 0.29a | 0.77 ± 0.27ab | 0.83 ± 0.28ab |
| Endometrial thickness (mm), median (Q1-Q3) | 10.80 (9.60–11.80) | 10.90 (9.60–12.50) | 11.10 (9.50–12.55) | 10.70 (9.45–12.00) |
| No. of retrieved oocytes, median (Q1-Q3) | 10.0 (7.0–12.0) | 12.0 (10.0–15.0a) | 14.0 (11.0–17.0)ab |
14.0 (12.0–17.5)ab |
| No. of inviable embryos, median (Q1-Q3) | 2.00(1.00–3.00) | 2.00 (2.00–2.00) | 2.00 (2.00–2.00) | 2.00 (1.00–2.00) |
| No. of embryos transferred, n (%) | ||||
| 1 | 167 (93.8%) | 278 (89.7%) | 223 (92.5%) | 54 (85.7%) |
| 2 | 11 (6.2%) | 32 (10.3%) | 18 (7.5%) | 9 (14.3%) |
Notes.
Data are presented as mean ± standard deviation unless otherwise indicated.
a
Compared with set 1, P < 0.05.
b
Compared with set 2, P < 0.05.
c
Compared with set 3, P < 0.05.
Abbreviations
- E2
- estradiol
- Q
- quartile
- BMI
- body mass index
- IVF
- in-vitro fertilization
- ICSI
- intracytoplasmic sperm injection
- FSH
- follicle stimulating hormone
- LH
- luteinizing hormone
- hCG
- human chorionic gonadotropin
- P
- progesterone