Table 3. Pregnancy and neonatal outcomes according to different E2 levels on hCG trigger day.
| Cleavage group | Blastocyst group | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Set 1 (n = 1208) | Set 2 (n = 584) | Set 3 (n = 320) | Set 4 (n = 105) | P-value | Set 1 (n = 178) | Set 2 (n = 310) | Set 3 (n = 241) | Set 4 (n = 63) | P-value | ||
| CPRs | 46.2% (558/1208) | 57.1% (333/584)a | 58.4% (187/320)a | 51.4% (54/105) | <0.001 | 56.2% (100/178) | 48.7% (151/310) | 54.4% (131/241) | 38.1% (24/63)a | 0.016 | |
| Miscarriage rate | 17.7% (99/558) | 13.8% (46/333) | 14.9% (28/187) | 7.4% (4/54) | 0.085 | 18.0% (18/100) | 14.5% (22/151) | 13.7% (18/131) | 0 | 0.052 | |
| Ectopic pregnancy rate | 2.2% (12/558) | 1.8% (6/333) |
1.6% (3/187) | 1.8% (1/54) | 0.745 | 0 | 0.6% (1/151) | 2.2% (3/131) | 0 | 0.231 | |
| Live birth rate | 37.1% (448/1208) | 48.1% (281/584)a | 48.7% (156/320)a | 46.7% (49/105)a | 0.002 | 46% (82/178) | 41.3% (128/310) | 45.6% (110/241) | 34.9% (22/63) | 0.175 | |
| singleton live birth rate | 27.4% (331/1208) | 32.2% (187/584)a | 35.3% (113/320)a | 31.4% (33/105) | 0.035 | 42.6% (76/178) | 35.5% (110/310) | 44.0% (106/241) | 34.9% (22/63) | 0.097 | |
| Preterm birth rate | 9.0% (30/331) | 6.4% (12/187) | 5.3% (6/113) | 15.2% (5/33) | 0.212 | 13.1% (10/76) | 10.9% (12/110) | 13.2% (14/106) | 13.6% (3/22) | 0.908 | |
| fetal weight | 3137 ± 498.4 | 3120 ± 482.7 | 3122 ± 465.2 | 3042 ± 498.8 | 0.760 | 3184 ± 455.0 | 3084 ± 495.1 | 3114 ± 495.5 | 3082 ± 519.4 | 0.206 | |
| LBW rate | 7.6% (25/331) | 8.0% (15/187) | 6.2% (15/113) | 15.2% (5/33) | 0.375 | 5.2% (4/76) | 4.5% (5/110) | 5.7% (6/106) | 9.1% (2/22) | 0.580 | |
| SGA rate | 6.9% (23/331) | 9.6% (18/187) | 14.2% (16/113) | 6.1% (2/33) | 0.111 | 5.3% (4/76) | 12.7% (14/110) | 12.3% (13/106) | 13.6% (3/22) | 0.285 | |
Notes.
Data are presented as mean ± SD or n (%).
a
Compared with set 1, P < 0.05.
Abbreviations
- E2
- estradiol
- CRP
- clinical pregnancy rates
- LBW
- low birthweight
- SGA
- small for gestational age