Table 7.
Toxicity parameter of selected metabolites.
| Toxicity parameter | Metabolites name |
|||
|---|---|---|---|---|
| Caledonixanthone E | Viniferin | Glaucine | Jatrorrhizine | |
| AMES Toxicity | Yes | Yes | No | No |
| Max. Tolerated Dose (log mg/kg/day) | 0.339 | 0.304 | 0.167 | −0.468 |
| hERG I inhibitor | No | No | No | No |
| hERG II inhibitors | Yes | Yes | Yes | Yes |
| Oral Rat Acute Toxicity, LD50 (mol/kg) | 2.131 | 2.441 | 3.219 | 3.089 |
| Oral Rat Chronic Toxicity, LOAEL (log mg/kg_bw/day) | 1.589 | 1.579 | 1.527 | 1.146 |
| Hepatotoxicity | No | No | No | Yes |
| Skin Sensitization | No | No | No | No |
| Minnow Toxicity (log mM) | 0.158 | 0.861 | 0.038 | 0.453 |