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Molecular docking models of COX-2 binding with celecoxib (A) and 5-fluorouracil (B), and EP4 and grapiprant (C) and 5-fluorouracil (D). The red spheroid illustrating the binding pocket of the receptor implies that the simulated binding site of the 5-fluorouracil does not match the natural one (celecoxib or grapiprant). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
