Table 2.
The signaling pathway of KEGG enrichment target number ≥10.
| ID | Pathway | Number of genes | Genes |
|---|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | 25 | CSF1R, GSK3B, RELA, EGFR, PIK3CG, IGF1R, RXRA, ERBB2, KDR, MAPK1, ITGAV, JAK2, MCL1, PDGFRB, NTRK1, HSP90AA1, BAD, PRKCA, MTOR, PIK3CA, CDK2, BCL2, MDM2, FGFR1, BCL2L1 |
| hsa04066 | HIF-1 signaling pathway | 14 | EGLN1, PFKFB3, NOS2, PRKCA, EGFR, MTOR, RELA, IGF1R, LDHB, LDHA, PIK3CA, ERBB2, BCL2, MAPK1 |
| hsa04668 | TNF signaling pathway | 14 | JUN, PTGS2, MAPK14, MMP9, RELA, ICAM1, MAPK11, CASP7, MAPK8, PIK3CA, CASP3, MAPK1, MAP3K8, MAP3K5 |
| hsa04657 | IL-17 signaling pathway | 13 | GSK3B, JUN, HSP90AA1, MMP1, PTGS2, MAPK14, MMP9, RELA, MAPK11, MAPK8, MMP13, CASP3, MAPK1 |
| hsa04010 | MAPK signaling pathway | 21 | PDGFRB, NTRK1, CSF1R, JUN, BRAF, PRKCA, MAPK14, EGFR, RELA, CDC25B, IGF1R, MAPK11, PPM1B, MAPK8, CASP3, ERBB2, KDR, MAPK1, MAP3K8, FGFR1, MAP3K5 |
| hsa04012 | ErbB signaling pathway | 12 | GSK3B, JUN, MAPK8, PIK3CA, SRC, BAD, ERBB2, MAPK1, BRAF, PRKCA, EGFR, MTOR |
| hsa04115 | p53 signaling pathway | 11 | CCNB2, CCNB1, CASP3, IGFBP3, CHEK1, CDK2, MDM2, BCL2, CDK1, BAX, BCL2L1 |
| hsa05206 | MicroRNAs in cancer | 20 | PDGFRB, ABCB1, HDAC1, PRKCA, CDC25C, PTGS2, SIRT1, MMP9, CDC25A, EGFR, MTOR, CDC25B, PIK3CA, CASP3, ERBB2, MDM2, PIM1, BCL2, MAPK1, MCL1 |
| hsa04068 | FoxO signaling pathway | 13 | BRAF, MAPK14, SIRT1, EGFR, IGF1R, MAPK11, CCNB2, CCNB1, MAPK8, PIK3CA, CDK2, MDM2, MAPK1 |
| hsa04015 | Rap1 signaling pathway | 15 | PDGFRB, CSF1R, SRC, BRAF, PRKCA, ITGAL, MAPK14, EGFR, IGF1R, MAPK11, PIK3CA, KDR, MAPK1, CTNNB1, FGFR1 |
| hsa04912 | GnRH signaling pathway | 10 | MAPK11, JUN, MAPK8, SRC, MMP2, PTK2B, MAPK1, PRKCA, MAPK14, EGFR |
| hsa04625 | C-type lectin receptor signaling pathway | 10 | MAPK11, JUN, MAPK8, PIK3CA, SRC, MDM2, MAPK1, MAPK14, PTGS2, RELA |
| hsa04620 | Toll-like receptor signaling pathway | 10 | MAPK11, JUN, MAPK8, PIK3CA, TLR9, MAPK1, TLR7, MAP3K8, MAPK14, RELA |
| hsa04660 | T cell receptor signaling pathway | 10 | MAPK11, GSK3B, JUN, MAPK8, PIK3CA, MAPK1, PTPN6, MAP3K8, MAPK14, RELA |
| hsa04014 | Ras signaling pathway | 14 | PDGFRB, NTRK1, CSF1R, BAD, PRKCA, EGFR, RELA, IGF1R, MAPK8, PIK3CA, KDR, MAPK1, FGFR1, BCL2L1 |
| hsa04152 | AMPK signaling pathway | 10 | CCNA2, PFKFB3, PIK3CA, FASN, PPARG, SIRT1, FBP1, CFTR, MTOR, IGF1R |
| hsa04621 | NOD-like receptor signaling pathway | 12 | P2RX7, MAPK11, HSP90AA1, JUN, MAPK8, BCL2, MAPK1, XIAP, MAPK14, RELA, CTSB, BCL2L1 |
| hsa04630 | JAK-STAT signaling pathway | 11 | PDGFRB, PIK3CA, BCL2, PIM1, PTPN6, JAK2, EGFR, PTPN2, MTOR, BCL2L1, MCL1 |
| hsa04915 | Estrogen signaling pathway | 10 | HSP90AA1, JUN, PIK3CA, SRC, MMP2, BCL2, MAPK1, ESR1, MMP9, EGFR |
| hsa04024 | cAMP signaling pathway | 12 | EDNRA, JUN, MAPK8, PIK3CA, BAD, ADORA1, MAPK1, BRAF, PPARA, GLI1, RELA, CFTR |