Fig. 5.

JuB inhibited tumor growth through antiangiogenic activity in a subcutaneous HCT-15 tumor model. (A) Tumor growth curve. (B) Tumor weight on day 15. (C) Body weight of mice. (D) Representative photographs of CD31-positive staining. (E) Quantified tumor microvessel density. (F) H&E staining sections of necrosis area. (G) Statistical analysis of necrosis area. (H) Proliferative tumor cells were stained by the Ki67 antibody. (I) Statistical analysis of Ki67-positive tumor cells. All values were shown as mean ± s.d. **p < 0.01, ***p < 0.001.