TABLE 1.
Pharmacokinetic parameters of glycycoumarin (GCM) after a single intravenous (i.v., 10 mg/kg) or oral (20 mg/kg) administration to rats. All data are expressed as the mean ± standard deviation (n = 6).
| Parameters | i.v. (10 mg/kg) | Oral (20 mg/kg) | |
|---|---|---|---|
| Free GCM | Total GCM | Total GCM | |
| Cmax (ng/mL) | - | - | 232.18 ± 78.30 |
| Tmax (h) | 0 | 0 | 0.79 ± 0.64 |
| C0 (ng/mL) | 5686.95 ± 1362.90 | 9727.38 ± 5068.72 | - |
| t1/2, λz (h) | 0.71 ± 0.11 | 2.46 ± 0.61 | 4.75 ± 0.46 |
| AUC0–t (ng h/mL) | 1163.66 ± 283.73 | 5033.80 ± 1840.97 | 983.23 ± 217.32 |
| AUC0–∞(ng h/mL) | 1169.64 ± 283.36 | 5521.77 ± 2112.90 | 1017.85 ± 238.94 |
| CL/F (L/h/kg) | 8.95 ± 2.0 | - | - |
| Vd, λz/F | 9.25 ± 3.13 | - | - |
| F (%) | - | - | 9.22 |
| Urine recovery (% of dose) | |||
| 0–12 h | 0.28 ± 0.25 | 0.74 ± 0.46 | |
| 12–24 h | 0.11 ± 0.10 | 0.23 ± 0.22 | |
| Bile recovery (% of dose) | |||
| 0–2 h | 0.20 ± 0.12 | 1.97 ± 0.59 | |
| 2–4 h | 0.08 ± 0.06 | 1.71 ± 0.55 | |
| 4–6 h | 0.05 ± 0.04 | 1.51 ± 0.38 | |
| 6–8 h | nd | 1.33 ± 0.96 | |
“–” not applicable; “nd” not detectable.