Table 3.

MDA Levels and SOD Activity in Liver Microsomes and Spleen Homogenates from Mice Treated with Three Doses of Oxi-CNOs

	Unt	Veh	125 µg	250 µg	500 µg	D-gal
MDA
Liver	0.96±0.07	0.90±0.03	0.92±0.07	0.88±0.07	0.94±0.12	ND
Spleen	0.82±0.07	0.94±0.07	0.86±0.10	0.88±0.14	0.78±0.13	2.31*
SOD
Liver	1.10±0.10	0.94±0.08	1.45±0.20	1.37±0.20	1.23±0.12	ND
Spleen	4.35±0.11	4.16±0.14	4.36±0.09	4.37±0.09	4.57±0.11	5.35*

Notes: Data are presented as the mean ± SEM of values expressed as nmol/mg protein (MDA) and U/mg protein (SOD), with n=5 mice per group. A mouse treated with D-galactose (D-gal) (300 mg/kg, ip, daily for 7 days) was used as positive control. Significance was determined with a one-way ANOVA coupled with a Tukey’s post-hoc test. *Significantly increased from all other corresponding treatment groups, p<0.05.

Abbreviations: Unt, untreated; Veh, vehicle control; ND, not determined.