Figure 4.

Fluorocitrate alleviated mechanical allodynia and thermal hyperalgesia in PIPN rats. (A) The effect on mechanical allodynia in rats (Group × Time interaction: F_12,40 = 26.05, p < 0.0001) (n = 3 rats per group). (B) The effect on thermal hyperalgesia in rats (Group × Time interaction: F_12,40 = 7.296, p < 0.0001) (n = 3 rats per group). (C) Immunohistochemical micrograph representing glial fibrillary acidic protein immunoreactivity in the spinal dorsal horns for each group. Scale bar = 200 μm. (D) Glial fibrillary acidic protein scores in the spinal dorsal horns. F_4,10 = 16.99 for (D). This experiment was independently repeated 3 times. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the Vehicle. ^#p < 0.05, ^## p < 0.01 and ^###p < 0.001 compared with the PTX. ^{^}p < 0.05 compared with the PTX + FC. NS, not significant compared with the Vehicle group. &, not significant compared with the PTX + FC.

Abbreviations: Abx, antibiotics; BL, baseline; d, day; FC, fluorocitrate; GFAP, glial fibrillary acidic protein; PTX, paclitaxel.