Table 2.
Comparison of the sensitivities and specificities of the CSF-VDRL, CSF-TRUST-10, and CSF-TRUST-17 tests for neurosyphilis diagnosis.
| Sensitivity comparison in neurosyphilis patients (n = 124) |
P1 |
Specificity comparison in syphilis/non-neurosyphilis patients (n = 86) |
P2 |
|||
|---|---|---|---|---|---|---|
| CSF-TRUST-10a | CSF-VDRL |
CSF-VDRL |
||||
| Positive | Negative | Positive | Negative | |||
| Positive | 57 | 0 | 0.500 | 0 | 0 | n.a. |
| Negative | 2 | 27 | 0 | 66 | ||
| CSF-TRUST-17 | CSF-VDRL | CSF-VDRL | ||||
| Positive | Negative | Positive | Negative | |||
| Positive | 85 | 0 | 0.125 | 0 | 0 | n.a. |
| Negative | 4 | 35 | 0 | 86 | ||
| CSF-TRUST-17 | CSF-TRUST-10a | CSF-TRUST-10a | ||||
| Positive | Negative | Positive | Negative | |||
| Positive | 57 | 0 | >0.999 | 0 | 0 | n.a. |
| Negative | 0 | 29 | 0 | 66 | ||
Abbreviation: CSF, cerebrospinal fluid; VDRL, venereal disease research laboratory; TRUST, toluidine red unheated serum test; n.a., not available.
a
The results of the CSF-TRUST-10 test were missing for 38 neurosyphilis patients and 20 syphilis/non-neurosyphilis patients.