Table 3.

The MR estimates, test of heterogeneity and test of pleiotropy of exposures on HCC based on AGEN.

Exposure	NSNP	MR methodology	Effect Estimates HCC				Test of heterogeneity		Test of pleiotropy
			OR	95%LCI	95%UCI	P value	Cochrane Q test	Phetero- geneity	MR Egger intercept	Ppleio- tropy
TG	8	IVW	1.134	0.938	1.371	0.193	21.467	0.003
		MR Egger	0.852	0.435	1.669	0.657	18.600	0.004	0.047	0.373
		Weighted median	0.972	0.771	1.224	0.808
TC	16	IVW	0.948	0.765	1.175	0.627	23.283	0.078
		MR Egger	0.879	0.489	1.582	0.674	23.149	0.058	0.008	0.780
		Weighted median	1.064	0.773	1.466	0.703
HDL-C	16	IVW	1.043	0.886	1.228	0.613	12.477	0.643
		MR Egger	1.079	0.764	1.524	0.672	12.429	0.572	−0.005	0.829
		Weighted median	1.047	0.835	1.314	0.689
LDL-C	13	IVW	0.911	0.762	1.089	0.308	17.837	0.121
		MR Egger	0.891	0.636	1.249	0.403	17.786	0.087	0.004	0.862
		Weighted median	0.975	0.772	1.232	0.813

Notes: NSNP is the number of single nucleotide polymorphism; The odds ratio (OR) is per 1 SD increase; 95%LCI is the lower limit of 95% confidence interval; 95%UCI is the upper limit of 95% confidence interval; P value is the p-value of OR; Pheterogeneity is the p-value of Cochrane's Q value in heterogeneity test; Ppleiotropy is the p-value of MR-Egger intercept.